“We are very pleased to have this IND under review by the FDA,” said Dr.
ATI-450, an investigational medicine formerly known as CDD-450, would be the first novel compound created by
Dosed orally, ATI-450 is a novel, selective MK2 (mitogen-activated protein kinase-activated protein kinase 2; MAPKAPK2) pathway inhibitor. MK2 is a key regulator of pro-inflammatory mediators including TNFα, IL-1β, IL-6, IL-8 and other essential pathogenic signals in chronic inflammatory and autoimmune diseases, as well as in cancer. Selective MK2 pathway inhibitors are being investigated for their potential ability to block inflammatory cytokine production and activity and, thereby, restore balance to the body’s immune system. Selective MK2 pathway inhibitors are also being evaluated in cancer models for their ability to block stromal inflammation and affect cell-cycle checkpoint activity. MK2 pathway inhibitors have the potential to treat patients with a variety of inflammatory and autoimmune diseases, as well as cancer. As an oral drug candidate, ATI-450 is being developed as a potential alternative to anti-TNF/anti-IL-1 biologics.
About Rheumatoid Arthritis
RA is the most common form of autoimmune arthritis. It affects more than 1.3 million Americans. About 75% of RA patients are women, and 1–3% of women may get rheumatoid arthritis in their lifetime. The disease most often begins between the ages of 30 and 50, and is a chronic disease which causes joint pain, stiffness, swelling, and decreased movement of the joints. Small joints in the hands and feet are most commonly affected, but RA can affect organs, such as eyes, skin or lungs.
Cautionary Note Regarding Forward-Looking Statements
Any statements contained in this press release that do not describe historical facts may constitute forward-looking statements as that term is defined in the Private Securities Litigation Reform Act of 1995. These statements may be identified by words such as "believe", "expect", "may", "plan," "potential," "will," and similar expressions, and are based on Aclaris' current beliefs and expectations. These forward-looking statements include expectations regarding the clinical development of ATI-450, including the timing for initiation of planned clinical trials. These statements involve risks and uncertainties that could cause actual results to differ materially from those reflected in such statements. Risks and uncertainties that may cause actual results to differ materially include uncertainties inherent in the conduct of clinical trials, Aclaris' reliance on third parties over which it may not always have full control, and other risks and uncertainties that are described in the Risk Factors section of Aclaris' Annual Report on Form 10-K for the year ended
Senior Vice President
Corporate Strategy/Investor Relations
Source: Aclaris Therapeutics, Inc.